Elected at 4th TAC National Congress, March 14-16 2008
The TAC secretariat is composed of the organisation's office bearers and is the day-to-day decision making body of the Treatment Action Campaign.
| Name | Position | Contact Details |
| Nonkosi Khumalo | Chairperson | 074 194 5911 |
| Teboho Klaas | Deputy Chairperson | 076 692 9583 |
| Vuyiseka Dubula | General Secretary | 082 763 3005 |
| Zackie Achmat | Deputy General Secretary | 083 777 9981 |
| Mark Heywood | Treasurer until June 2008 | 083 634 8806 |
| Nathan Geffen | Treasurer from July 2008 | 084 542 6322 |
The Provincial Council representatives were elected at TAC's six provincial congresses held in the first quarter of 2008 before the National Congress.
| Name |
Position | Province | Contact Details |
| Fredalene Booysen | Provincial Coordinator | Western Cape | 073 206 3611 |
| Ntombozuko Kraai | Deputy Chairperson | Western Cape | 073 354 1085 |
| Portia Ngcaba | Provincial Coordinator | Eastern Cape | 078 456 9102 |
| Anele Yawa | Deputy Chairperson | Eastern Cape | 083 495 4055 |
| Gordon Mthembu | Provincial Coordinator | Gauteng | 078 456 3845 |
| Bheki Khoza | Provincial Coordinator | Mpumalanga | 078 603 0498 |
| Bongi Skhosana | Secretary | Mpumalanga | 073 475 7299 |
| Phillip Mokoena | Provincial Coordinator | KZN | 078 456 3847 |
| Gugu Mpungose | Secretary | KZN | 078 224 2276 |
| Eddy Tinyiko Marilele | Deputy Chairperson | Limpopo | 083 687 4527 |
| Solanga Solly Milambo | Secretary | Limpopo | 072 865 7771 |
The sector representatives were elected at the 4th National Congress.
| Name | Position | Contact Details |
| Sidumo Dlamini | Labour Rep. | |
| Bukelwa Voko | Children's Rep. | 082 945 8504 |
| Lihle Dlamini | Women's Rights Campaign Rep. | 073 152 1952 |
| Emma Baleka | Women's Rights Campaign Rep. | |
| Mashudu Mfomande | People Living With HIV Rep. | 072 095 9327 |
| Thuli Manikela | People Living With HIV Rep. |